You can naturally get your body to make more NAD+ by boosting the NAD+ synthesizing enzyme NAMPT.

Particular caution should be used for NAD+-boosting supplements by those with cancer, a personal or strong family history of cancer and perhaps also by those with inflammatory disorders and certain active infections.

What happened when topical olive oil was pitted against an ibuprofen-type drug for osteoarthritis and rheumatoid arthritis?

What are the pros, cons, and efficacy of dihydronicotinamide riboside (reduced NR), perhaps the most potent NAD+ precursor, as well as reduced NMN, taking NAD+ directly, or making it from scratch from tryptophan?

NR may just be a waste of money, safe but ineffective. NMN seems similarly useless in humans, but it may not even be safe.

Common drugs, foods, and beverages can disrupt the integrity of our intestinal barrier. Which foods should we avoid to prevent leaky gut? Which foods and food components can boost the integrity of our intestinal barrier?

The suppression of NAD+ synthesis by NR in humans may explain the disparate rodent results.

The metabolism of NAM may deplete our methylation capacity, interfering with the normal metabolism of hormones and neurotransmitters, and produce a neurotoxic compound in the process.

What did randomized controlled human trials find about the ways we may—or may not—benefit from eating onions?

Given niacin’s decades of use as a cholesterol drug, we have a good idea of its safety profile.